Popular weight-loss drugs may ease migraines too

A GLP-1 drug led to fewer days with headaches, a small pilot study of migraine sufferers shows. It may work by lowering pressure inside the head.

Jul 1, 2025 - 23:30
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Popular weight-loss drugs may ease migraines too

A GLP-1 drug ended in fewer days with headaches, a small search for of migraine victims displays

A girl alongside with her eyes closed holds her foreheadin inconvenience.

A GLP-1 drug decrease the sequence of days that folks experienced migraine, possibly by reducing the rigidity throughout the cranium, researchers suspect.

Delmaine Donson/Getty Photos

GLP-1 pills may salvage a new vitality: Easing migraines. In a small, preliminary search for, a GLP-1 drug virtually halved the sequence of days other folks spent with a migraine in a given month.

The outcomes, presented June 21 on the European Academy of Neurology Congress in Helsinki, Finland, amplify the that that likelihood is you'll deem of advantages of the significant new class of weight problems and diabetes pills. These pernicious, debilitating headaches are estimated to have an impact on a billion other folks worldwide.

Earlier reports have shown that GLP-1 agonists can decrease the rigidity throughout the cranium, a squeeze that’s been implicated in migraines. Neurologist Simone Braca of the University of Naples Federico II in Italy and his colleagues explored whether liraglutide, an older relative of Ozempic and Wegovy, may possibly aid migraine victims. Thirty-one adults, 26 of them females, purchased day after day injections of liraglutide for 12 weeks. These adults all had weight problems and continued to preserve discontinuance their recent migraine medicines too.

On the originate of the experiment, contributors had headaches on about 20 days out of a month. After 12 weeks of liraglutide, the moderate number dropped to about 11 days. “In overall, we observed that sufferers observed their days with headache halved, which is titanic,” Braca says. Participants’ weight stayed relating to the an analogous all the plot throughout the trial, suggesting that headache reductions weren’t tied to weight reduction.

If the outcomes lengthen in bigger reports, they'll voice therapies for migraine victims who aren’t helped by existing pills. The outcomes may lead to a deeper thought of the role of rigidity throughout the head in migraines, Braca says.

The trial, described in Headache June 17, used to be an early gape on the outcomes of liraglutide on migraines; it didn’t contain a comparison community, and contributors and researchers all knew that all americans purchased liraglutide. Greater trials that contain comparison groups, and possibly other folks with out weight problems, will elaborate the drug’s design on headaches.

A brand new class of migraine pills, referred to as CGRP blockers, has been extremely effective for loads of contributors, nonetheless they don’t aid all americans, Braca says. “What I'd want to order to these sufferers is that study goes forward.”

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