U.S. FDA may nix black box warning on some menopause estrogen treatments
Experts worry the warning on vaginal estrogen menopause treatments is doing more harm than good and is not supported by science.
Citations
A. L. Hirschberg. Enhancing quality of existence: addressing vulvovaginal atrophy and urinary tract symptoms. Climacteric. Printed online June 18, 2025. doi: 10.1080/13697137.2025.2514029.
R.J. Santen, et al. Systemic estradiol phases with low-dose vaginal estrogens. Menopause. Vol 27, March 2020, p. 361. doi: 10.1097/GME.0000000000001463.
S.N. Bhupathiraju, et al. Vaginal estrogen expend and continual illness risk within the Nurses’ Neatly being Scrutinize. Menopause. Vol. 26, June 2019, p. 603. doi: 10.1097/GME.0000000000001284.
L.M. Chambers, et al. Vaginal estrogen expend for genitourinary symptoms in ladies folks with a history of uterine, cervical, or ovarian carcinoma. Global Journal of Gynecological Cancer. Vol. 30, April 2020, p. 515. doi: 10.1136/ijgc-2019-001034.
V. M. Miller, et al. Lessons from KEEPS: the Kronos Early Estrogen Prevention Scrutinize. Climacteric. Vol. 24, 2020, p. 139. doi: 10.1080/13697137.2020.1804545.
Sofia Caetano Avritzer is the 2025 AAAS Mass Media Fellow with Science Files. She has a Ph.D. in neuroscience from The Rockefeller College, where she studied how fruit flies transfer their eyes and navigate the field.
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